Psoriasis as a risk factor for development of erectile dysfunction: An observational cross-sectional study was conducted in Portugal to study the prevalence and causes of erectile dysfunction in patients with psoriasis. For this purpose, anonymous questionnaires of the Dermatological Quality of Life Index (DLQI) and the 5th edition of the International Erectile Function Index were consistently collected, filled out by 135 adult men suffering from psoriasis and 201 men with other skin diseases.
The results of the study showed that patients with psoriasis had a higher prevalence, as well as an increased risk of developing more severe forms of erectile dysfunction, than in the control group (61.5% vs. 43.8%, respectively, p=0.001). At the same time, the localization of rashes on the skin of the genitals and the duration of the dermatological disease were not associated with disorders of the sexual sphere. When analyzing multivariate logistic regression, data were obtained that allow us to consider psoriasis and diabetes mellitus as risk factors for the development of erectile dysfunction with an estimated ratio coefficient of 2.28 (CI 95%, 1.40-3.27) and 3.49 (CI 95%, 1.40-8.66), respectively.
The results of the study suggest that psoriasis is an independent risk factor for the development of erectile dysfunction. At the same time, atherosclerosis is a likely cause of the development of sexual disorders in men, along with the negative influence of psychological factors in these patients. In addition, it has been shown that the occurrence of erectile dysfunction can precede the early manifestation of cardiovascular diseases and can be regarded as an early marker of the risk of cardiovascular diseases in men with psoriasis.
The presence of a hereditary predisposition to the development of psoriasis
Ricci C. – To assess the impact of a burdened family history on the risk of developing psoriasis, the medical histories of 640 patients with plaque psoriasis were studied.
The results of the study showed that a positive family history was detected in 380 (27.18%) patients. Of these, 174 (27.18%) had at least one parent suffering from psoriasis, 106 (16.56%) patients had at least one second – degree relative with psoriasis, and 34 (5.31%) had one third-degree relative with psoriasis. At the same time, there were no reliable data on the predominant inheritance of psoriasis on the maternal or paternal side, as well as the relationship between the features of the course of psoriasis and the presence/absence of a burdened family history.